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Signum's Scientific Advisory Board
Signum has assembled a group of experienced and distinguished experts to provide it with critical counsel and feedback about the company's strategy and its execution of that strategy. The diverse nature of Signum's planned product lines, its innovative fusion of pharmaceutical and consumer research, its divergent marketing challenges, and its heavy reliance on collaborations and partnerships make it critical for the company to have timely access to critical strategic thinkers with broad interdisciplinary experience, and a familiarity with Signum's larger strategy.
General Advisory Board
GPM Scientific Advisors
PPM Scientific Advisors
Thomas Shenk, PhD
Advisory Board Chairman
Thomas is the Elkins Professor of Molecular Biology at Princeton University. He is a member of the National Academy of Sciences and a past president both of the American Academy of Microbiology and the American Society for Virology. He serves on the Board of Directors of Merck & Co. and Cell Genesys.
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Herb Brotspies, DBA
Herb, who spent 20 years at Bristol-Myers Squibb, was the Director of Marketing there before becoming VP of Business Development, a position he also held at Pharmacia for 5 years. He has executed brand marketing plans for products including Excedrin, Ban and Comtrex, negotiated drug and consumer product licenses, initiated Rx to OTC switches, orchestrated joint ventures, and evaluated and managed acquisitions.
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George Kooluris
George spent over 30 years with Bristol-Myers Squibb, most recently as Senior Vice President of Corporate Development. At BMS, he was responsible for some 150 mergers, acquisitions, joint ventures and divestitures worldwide including the merger of Bristol Myers with Squibb and the sale of Clairol to Procter & Gamble.
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Gerry Miller
Gerry has spent 30 years in advertising, creative direction and brand management at Leo Burnett, where he rose to be Executive VP and Executive Creative Director. He has been responsible for campaigns for Procter & Gamble, Kellogg’s, Nestle, McDonalds, and Tropicana, as well as launches or major repositionings of Celebrex, Prozac, Allegra and Nature Made. He is the recipient of several Clio’s, the New York Art Director’s Award, and the Cannes Gold Lion.
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Martin Semmelhack, PhD
Martin, a Professor in the Chemistry Department at Princeton University, served on the editorial boards of the Journal of Organic Chemistry, Organometallics, and Organic Reactions, edited two texts on organic synthesis, and was on the Executive Committee of the Organic Chemistry Division of the American Chemical Society. He also has served as the Consulting Director of Chemistry at the American Cyanamid Medical Research Division. Semmelhack has collaborated with Professor Stock for many years and is working with Signum to understand the chemistry of Arazine-like compounds and identify active STMs in coffee and other botanicals. His laboratory is a key collaborator on Signum’s NJCST grant to develop the pharmaceutical potential of Cognion™.
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Pierluigi Zappacosta
Pierluigi co-founded Logitech in 1981 and served there as President and CEO then as Vice-Chairman. He currently chairs Digital Persona, the leader in personal biometric identification systems, and is the Acting President of Sierra Sciences, a biotech working on Telomerase control. A seasoned entrepreneur, he was our first outside investor. Howard Stevenson, PhD, chairs the Owner/President Program in Executive Training at Harvard Business School, where he is the Sarofim-Rock Professor of Business Administration, a chair established to provide for research and teaching of entrepreneurship. He has authored, edited or co-authored six books including: New Business Ventures and the Entrepreneur and Do Lunch or Be Lunch.
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Arshad Zakaria
Arshad was Executive VP and Chairman of the Global Markets and Investment Banking Group at Merrill Lynch until 2004 when he founded New Vernon Capital, a hedge fund that has since grown to $1 B in assets. He received his MBA from Harvard and is on the Board of Directors of The NASDAQ Stock Market and the Cancer Institute of New Jersey. Lynn Enquist, PhD, the Chair of the Department of Molecular Biology at Princeton University is Editor-in-Chief of the Journal of Virology, President of the American Society for Virology, and a member of the AAAS board of directors. He also was commissioner of the New Jersey Cancer Commission and has led a variety of corporate and government research programs.
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Edward Cox, PhD
Edward is the Edwin Grant Conklin Professor of Biology at Princeton University and the director of the Program on Biophysics. For a decade he chaired Princeton’s Department of Biology. He also served as Chairman of the Basic Cancer Research Advisory Group for the State of New Jersey.
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Carl Ehmann, MD
Carl has served as the Director of Clinical Research in Dermatology at Hoffmann-La Roche, as the VP of Pharmaceutical Research and Development for Dermatology at Bristol Myers, as the Executive VP of Consumer Products Worldwide at Johnson & Johnson, and as the President of Reynolds Technologies. He is currently on the Board of Directors of Barrier Therapeutics.
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Joel Gordon , PhD
Joel received his PhD from the University of Pennsylvania and spent 18 years at Johnson & Johnson. He was a Senior Scientist on the team that led the development effort on retinol there and is intimately familiar with developing successful dermal agents. He also led programs on the mechanisms of skin aging and various other projects involving therapeutic skin care biology. Currently Dr. Gordon serves as an independent consultant for Signum.
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Richard Granstein, MD
Richard, the George Hambrick Professor of Dermatology at Cornell, has chaired the Department of Dermatology at the Cornell Weill Medical Center and been Dermatologist-in-Chief at the New York Weill Cornell Medical Center of New York-Presbyterian Hospital since 1995. Previously, he was on the faculty of the Harvard Medical School. His research and clinical interests include autoimmune disorders, skin cancer and psoriasis.
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Suzan Obagi, MD
Suzan has written numerous articles and book chapters on skin health restoration, chemical peeling, dermabrasion and laser resurfacing. She has given lectures to ophthalmologic, oral maxillofacial and dermatologic surgeons on the dermatologic approach to the cosmetic patient and on the different methods of peeling. Dr. Obagi is assistant professor in dermatology at the University of Pittsburgh and Director of the Cosmetic Surgery and Skin Health Center.
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John Seykora , MD, PhD
John received his PhD from Rockefeller University and his MD from Cornell University Medical College. He is currently an assistant professor University of Pennsylvania (Dermatology Department), where his lab characterizes the molecular mechanisms that keratinocytes use to regulate growth and differentiation. Also, utilizing microarrays, Dr. Seykora’s lab is characterizing molecular features of normal and diseased human tissue.
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Jeffery Cummings, MD
Jeffery is the Augustus S. Rose Professor of Neurology and is also Professor of Psychiatry and Biobehavioral Sciences at UCLA. He is Founder and Director of the UCLA Alzheimer’s Disease Center and directs the UCLA Behavioral Neuroscience and Dementia Research Fellowship. Many of the approximately 40 fellows that he has trained currently hold leadership positions in dementia programs throughout the United States and the world. He is the Founder and Director of the Deane F. Johnson Center for Neurotherapeutics at UCLA. Jeffrey's interests embrace clinical trials and the development of new treatments for neurodegenerative disorders and other neurological diseases. He is past president of the Behavioral Neurology Society and of the American Neuropsychiatric Association and in 2005 was named Edward Henderson State-of-the-Art Lecturer by the American Geriatrics Society. He has authored or edited 20 books and over 450 peer reviewed papers.
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Khalid Iqbal, PhD
Khalid received his PhD in Biochemistry from the University of Edinburgh, where he carried out pioneering research on Alzheimer neurofibrillary degeneration. He is currently Professor and Chairman, Department of Neurochemistry, at the New York State Institute for Basic Research in Staten Island, New York and co-founded the biennial International Conferences on Alzheimer’s Disease & Related Disorders, (ICAD). Dr. Iqbal has authored over 200 scientific papers in prestigious American and international scientific journals and edited eight books on research advances in Alzheimer’s Disease. His major research interests are the neurobiology of Alzheimer disease and related neurodegenerative disorders, especially the molecular mechanisms of neurofibrillary degeneration, a specific type of nerve cell death which predominates Alzheimer disease and related disorders. His pioneering studies on neuronal protein pathology and discoveries of the involvement of the tau protein and its abnormal hyperphosphorylation in Alzheimer disease have won him several prestigious honours and awards, including the Potamkin Prize from the American Academy of Neurology and the Zenith Award from the Alzheimer’s Association, U.S.A.
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Yigong Shi, PhD
Yigong, a Professor of Molecular Biology at Princeton University, is a prolific x-ray crystallographer and a leading expert on structure-function relationships in apoptosis. He was a founder of Gentara Corporation and is a member of the company’s Scientific Advisory Board.
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Scott Vafai, MD
Scott is a graduate of Harvard Medical School currently training in internal medicine at Brigham and Women's Hospital. As an undergraduate at Princeton, he worked with Dr. Jeffry Stock to develop a model linking PP2A methylation to Alzheimer's disease pathogenesis. He continues to work with Signum to develop therapeutics targeting the PP2A methylation system.
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