Cognion™ and the Promise of PP2A:

To sustain focus and concentration your brain requires healthy communication between neurons. Cognion™ represents a novel nutraceutical which:

• helps protect neuronal structural integrity to allow robust protein signaling.
• optimizes the function of a central regulator of cell health, PP2A, and enhances a pathway that is degraded with stress and aging.
• increases PP2A activity (the major tau dephosphorylation enzyme in the brain) which in turn increases cognitive and metabolic function.
• Keeps brain circuits involved in memory in good condition and reduces susceptibility to neurodegeneration.

What is Cognion™?

Signum scientists identified SIG1012, a bioactive molecule found in coffee. From this discovery we developed Cognion™, a proprietary coffee extract that contains high levels of SIG1012. The process of making Cognion™

starts with a rough coffee extract that is screened, looking for PP2A activity. Several botanical processes occur to define and refine the extract, and the end result is Cognion™.

The Opportunities

• Cognion™ has been shown to be beneficial in in vivo models of cognition, memory and motor function.
• Efficacy studies have been published in The Journal of Neuroscience and Future of Medicinal Chemistry.
• Potential consumption benefits include: cognitive performance and mental acuity, cardio-protection, anti-diabetic, anti-cancer, and sports performance.
• Cognion™ protects memory function, improve thinking and reasoning, enhances brain health and brain function and delays late life forgetfulness.