Our ongoing research with botanical extracts, have initially focused on coffee, which is a rich source of anti-oxidants and the subject of substantial data showing large health benefits. Signum’s lead dietary-supplement is Cognion™, a coffee extract enriched for naturally occurring PPMs. Cognion™ enhances PP2A activity, by inhibiting demethylation and thus promoting phosphatase activity. Heavy coffee drinkers have been shown to have a reduced risk of Alzheimer’s, Parkinson’s and type-2 diabetes. We expect Cognion™ to provide many of the health benefits of coffee, by performing as a metabolic-balancing and cognitive-health enhancing supplement.
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