Signum Biosciences business strategy and R&D program are well aligned to discover, develop proprietary Signal Transduction Modulators (STM). These compounds compensate for signaling imbalances that diminish health and cause disease. We are focused on therapeutics that are well protected by intellectual property and are developing them for indications that can be commercialized in the near term. We are spinning off FDA-exempt skincare and nutraceutical products to build early revenue while we advance our anti-inflammatory and CNS pharmaceutical candidates which we expect to out-license to pharmaceutical compnies. We maintain a modest burn rate by taking advantage of academic and corporate collaborations to effect basic research, by carefully organizing testing and preclinical development, and by targeting indications with inexpensive development paths.