See attached document. Signum’s work, in collaboration with M.Mouradian M.D of Rutgers-Robert Wood Johnson Medical School, on efficacy of inhibiting PP2A demethylation in a model of Parkinson’s disease has been published in the prestigious Journal of Neuroscience. This work for the first time links PP2A to alpha-synuclein dephosphorylation in a methylation dependent manner and demonstrates the efficacy of pharmacological modulation of this mechanism for disease modification in an alpha-synuclein transgenic model.

Enhanced Phosphatase Activity Attenuates α-Synucleinopathy in a Mouse Model. The Journal of Neuroscience, 11 May 2011, 31(19):6963-6971.