Our scientific team was invited to Seoul South Korea to discuss the science behind SIG1273, our 2nd generation isoprenylcysteine (IPC) cosmetic functional ingredient (CFI) and eicosanoyl-5-hydroxytryptamide, Signum's naturally occurring, proprietary extract found in coffee. At the cellular level, SIG1273 has to the ability to inhibit the production of pro-inflammatory cytokines and prevent the oxidative damage associated with chronic inflammation and stress. SIG1273 has been clinically proven to be safe and effective in protecting the skin from inflammatory and microbial invaders. It was also designed to possess anti-aging and anti-microbial properties. Click on this link to learn more about SIG-1273

Eicosanoyl-5-hydroxytryptamide was identified as a component of coffee that interacts with the primary phosphoprotein phosphatase in neuronal tissue, PP2A. Research with well-defined biochemical systems composed of purified enzymes showed that EHT inhibits PP2A demethylation with an IC50 of 4 µM. In addition, EHT was shown to be efficacious in cell culture, inhibiting demethylation of PP2A in hippocampal neurons. Thus, EHT acts as a PP2A activator to stabilize the AB55αC form of PP2A and thereby boost PP2A’s ability to modulate cytotoxic neuronal stress response mechanisms.     Click on this link to review our scientific papers