Signum researchers attended this years Society for Investigative Dermatology (SID). They  presented two posters this year One titled, “SIG1191: A Novel Cosmetic Functional Ingredient with Anti-inflammatory Properties and Skin Hydrating Potential” and the other "SIG1273: A Skin Protecting Cosmetic Functional Ingredient with a broad spectrum of anti-aging and anti-inflammatory properties". SIG1191: SIG1191 shows anti-inflammatory activity in the TPA-induced pro-inflammatory cytokine production in primary human keratinocytes. SIG1191 also demonstrates anti-inflammatory properties invitro reducing UVA-induced cytokines in cultured dermal fibroblasts. Furthermore, SIG1191 inhibits inflammatory mediator COX-2 gene expression in cultured skin equivalents. In addition to its anti-inflammatory properties, we present there that SIG1191 potentially targets skin hydration and aging by modulating Aquaporin-3 (AQP3) expression.

SIG1273: SIG1273 successfully blocks UVA-induced IL-6 and MMP-1 production in HDFs. In addition, SIG1273 accelerates fibroblast migration in an invitro wound-healing model. Moreover, SIG1273 displays antioxidant properties blocking urban dust induced oxidation and cytotoxicity in keratinocytes, which is further supported by free radical scavenging capacity.

See links below for the posters presented at the SID.



Society for Investigative Dermatology (Atlanta, Georgia   May 6-9, 2015)