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SIG-1459

Eicosanoyl-5-HydroxyTryptamide

1. Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid. Kesava Asam1,2, Agnieszka Staniszewski1,2, Hong Zhang1,2, Scott L. Melideo3, Adolfo Mazzeo1,2, Michael Voronkov4, Kristen L. Huber4, Eduardo Pe ´rez4, Maxwell Stock4, Jeffry B. Stock3,4, Ottavio Arancio1,2,5, Russell E. Nicholls1,2* (2017)

2.  Neuroprotective and Anti-inflammatory Properties of a Coffee Component in the MPTP Model of Parkinson’s Disease.Kang-Woo Lee, Joo-Young Im, Jong-Min Woo, Hilary Grosso, Yoon-Seong Kim, Ana Clara Cristovao, Patricia K. Sonsalla, David S. Schuster, Marla M. Jalbut, Jose R. Fernandez, Michael Voronkov, Eunsung Junn, Steven P. Braithwaite, Jeffry B. Stock, and M. Maral Mouradian, Neurotherapeutics. 2013

3. Therapeutic benefits of a component of coffee in a rat model of Alzheimer disease. Neurobiology of Aging, 2014.   Basurto-Islas, G., Blanchard, J., Tung, Y. C., Fernandez, J. R., Voronkov, M., Stock, M., Zhang, S., Stock, JB., Iqbal, K. (2014). 

4. Enhanced Phosphatase Activity Attenuates α-Synucleinopathy in a Mouse Model. Neurobiology of Disease, 2011. Lee KW, Chen W, Junn E, Im JY, Grosso H, Sonsalla PK, Feng X, Ray N, Fernandez JR, Chao Y, Masliah E, Voronkov M, Braithwaite SP, Stock JB, Mouradian MM.

SIG-1191™

1. SIG-1191: A novel cosmetic functional ingredient with anti-inflammatory properties and skin hydrating potential
   Fernandéz JR, Rouzard K, Voronkov M, Huber KL, Webb C, Stock JB, Stock M, Gordon JS, Pérez E. Society for Investigative Dermatology. Poster presentation.
2. SIG-1191TM: A novel hydrating cosmetic functional ingredient (CFI) for suborbital hyperpigmentation (under eye dark circles) José R. Fernández, Karl Rouzard, Michael Voronkov, Jason Healy, Kristen L. Huber, Corey Webb, Jeffry B. Stock, Maxwell Stock, Joel S. Gordon, Eduardo Pérez. Society for Investigative Dermatology, Scottsdale, Arizona 2016. Poster presentation
3. N-Acetylglutaminoyl-S-Farnesyl-L-cysteine (SIG-1191): an anti-inflammatory molecule that increases the expression of the aquaglyceroporin, aquaporin-3, in human keratinocytes
   José R. Fernández, Corey Webb, Karl Rouzard, Michael Voronkov, Kristen L. Huber, Jeffry B. Stock, Maxwell Stock, Joel S. Gordon, Eduardo Pérez. Arch Dermatol Res (2016)

SIG-1273™

1. In vitro and clinical evaluation of SIG-1273: a cosmetic functional ingredient with a broad spectrum of anti-aging and antioxidant activities. Fernandéz JR, Rouzard K, Voronkov M, Huber KL, Stock JB, Stock M, Gordon JS, Pérez E. J Cosmet Dermatol. 2016 Jan 11. doi: 10.1111/jocd.12206.
2. Anti-inflammatory and anti-bacterial properties of tetramethylhexadecenyl succinyl cysteine (SIG-1273): a skin-protecting cosmetic functional ingredient. Fernandéz JR, Rouzard K, Voronkov M, Huber KL, Stock JB, Stock M, Gordon JS, Pérez E. Int J Cosmet Sci. 2014 Sep 25. doi: 10.1111/ics.12166.
3. SIG-1273: a new cosmetic functional ingredient to reduce blemishes and Propionibacterium acnes in acne prone skin. Fernandéz JR, Rouzard K, Voronkov M, Feng X, Stock JB, Stock M, Gordon JS, Shroot B, Christensen MS, Pérez E.J Cosmet Dermatol. 2012 Dec;11(4):272-8.
4. Anti-inflammatory, anti-aging, and anti-bacterial properties of SIG-1273: A skin protecting cosmetic functional ingredient
   Fernandéz JR, Rouzard K, Voronkov M, Huber KL, Webb C, Stock JB, Stock M, Gordon JS, Pérez E. Japanese Society of Investigative Dermatology. Poster presentation.
5. Optimera® firming body contour cream contains SIG-1273, a molecule with cell lipolysis and anti-aging properties that clinically promotes skin firmness
   José R. Fernández, Karl Rouzard, Michael Voronkov, Kristen L. Huber, Corey Webb, Jeffry B. Stock, Maxwell Stock, Joel S. Gordon, Jason Healy, Pilar P. Duque, Wendi L. Armbrister, Stephen R. Schwartz, Robigaile Atienza, Eduardo Pérez. Society for Investigative Dermatology 2016, Scottsdale, Arizona. Poster presentation

Australia Grand Opening Presentation, Maxwell Stock, President and CEO, March 24th &25th

Colombia Grand Opening
 

Japan Regional Event
(Japanese Version)

Latino Regional Event – Orlando    Orlando Regional Spanish Presentation, Eduardo Perez, CSO, December 9, 2017

Enfócate 2018                               Bogotá, Colombia Spanish Presentation, Eduardo Perez, CSO, January 20, 2018